Lyophilized cytoxan cyclophosphamide for injection, usp. Based on the linear regression analysis of cyclophosphamide concentrations expressed as a percent of the initial values, cyclophosphamide in simple syrup is degraded by 10% after 10. Dailymed cyclophosphamide injection, powder, for solution. Cyclophosphamide is soluble in water and in alcohol. Cyclophosphamide oel fastrac with ade affygility solutions. A few of the types of cancer that it may be used to treat include leukemia, ovarian cancer, and lymphomas. Metabolic acidosis was reported in 31% of patients in one study when ifex was administered at doses of 2. Cyclophosphamide is a white crystalline powder with the molecular formula c7h15cl2n2o2ph2o and a molecular weight of 279. We also mapped drug names to rxnorm codes and created optional filters. Pdf effect of cyclophosphamide on haematological profiles. Cyclophosphamide is an iarc group 1 agent as a confirmed human carcinogen. Cyclophosphamide does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions.
Cyclophosphamide induced sterility may be irreversible in some patients. Cyclophosphamide for injection, usp is a sterile white cake available as 500 mg, 1 g, and 2 g strength vials. Doses 500 mg to approximately 2 grams may be administered over 2030 minutes. Cyclophosphamide 2000 mg powder for solution for injection or infusion is packed in boxes containing. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Cyclophosphamide for injection, usp is for intravenous or oral use, it has no inactive ingredients. The results of a recent phase 2 clinical trial comparing four velcadebased combination therapies in newly diagnosed multiple myeloma patients show that a fourdrug combination containing velcade, revlimid, cyclophosphamide, and dexamethasone led to similarly high response rates as the threedrug regimens, but resulted in a higher rate of side effects. In addition, cyclophosphamide has benn associated in experimental animal studies and human case reports with adverse effects on fertility and embyro development. For the majority of arylamines, adding 3fluorobenzyl bromide at this point. This article also lists some offlabel uses such as treating aplastic anemia. Cyclophosphamide cytoxan is a chemotherapy drug prescribed for nonhodgkin lymphoma, hodgkin lymphoma and multiple myeloma to name a few. Cyclophosphamide should be prepared for parenteral use by adding 0.
Cyclophosphamide is well absorbed after oral administration with a bioavailability greater than 75%. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for cytoxan cyclophosphamide skip to. Cyclophosphamide comes as a tablet to take by mouth once a day. Information for the patient mock up cyclophosphamide 50 mg tablets by caroline mcdermott at this product is available as the above name but will be referred to as cyclophosphamide throughout the following leaflet. Dec 14, 2016 cyclophosphamide tablets are for oral use. Inactive ingredients in cyclophosphamide tablets are. The american academy of pediatrics considers cyclophosphamide a cytotoxic drug that may interfere with the cellular metabolism of a nursing infant. Less commonly, this drug is also injected directly into muscle, abdominal lining, or lung lining. Patients will not receive any study drugs during the final week of each induction cycle. Reconstitute the cyclophosphamide for injection with the 0. The wordpress plugin directory is the largest directory of free and open source wordpress plugins. There are thousands of free and paid plugins available and in this video, we will show you how to install a wordpress plugin. Then enter your websites original language and the translation languages you want. A wordpress plugin is a program or a set of one or more functions written in the php scripting language, that adds a.
Because of the potential for serious adverse reactions and the potential for tumorigenicity shown for cyclophosphamide in humans, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Procedure separately inject equal volumes about 25 l of the standard preparation and the assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. Cyclophosphamide is soluble in water, saline and ethanol. Before all analytic runs, all standards, quality controls and cyclophosphamide stability samples were diluted to a 20x final dilution in 20% methanol80% ddh 2 o. Cyclophosphamide should only be administered where there are facilities for regular monitoring of clinical, biochemical and haematological parameters before, during, and after administration and under the direction of a specialist oncology service.
Cyclophosphamide, an alkylating agent, has been used as an immunosuppressant in the treatment of various autoimmune disorders and malignancies. After cyclophosphamide treatment of patients with systemic lupus erythematosus and dermatomyositis. Cyclophosphamide should only be used by clinicians experienced in the use of cancer chemotherapy. Cyclophosphamide cyc is an alkylating agent that was introduced into clinical practice as a chemotherapeutic agent but has also been used to treat a number of systemic autoimmune diseases. The risk of opportunistic infection such as pneumonia secondary to pneumocystic carinii increases drastically with lymphopaenia. Cyclophosphamide manufacturer pharmacological index neoplastic disorders india,tablets,exporter india,capsules,injections,gelatin cyclophosphamide 50mg,cyclophosphamide 200mg,cyclophosphamide 1g largest generic manufacturer,composition,drugs,formula,producing cyclophosphamide,msds,coa, pdf,doc chemical api method according to the present. Cyclophosphamide is used to treat various types of cancer.
Development of sterility appears to depend on the dose of cyclophosphamide, duration of therapy, and the state of gonadal function at the time of treatment. Cyclophosphamide also works by decreasing your immune systems. The following side effects have been seen in people using cyclophosphamide with other chemotherapy drugs, so some of these effects may also be related to chemotherapy. Oral cyclophosphamide given in repeated low dose pulses 5 mgkg for 3 consecutive days is better tolerated with regard to nausea than intravenous administration. For aldh1a1, the 3fluorobenzyl ring engages in pipi interactions. Cyclophosphamideinduced sterility may be irreversible in some patients.
Incidence of cyclophosphamideinduced urotoxicity and protective effect of mesna in rheumatic diseases. Read all of this leaflet carefully before you start taking this medicine because it contains important information. Sep 17, 2019 cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Oct 08, 2019 cyclophosphamide interferes with oogenesis and spermatogenesis. Take cyclophosphamide at around the same time every day. Follow the directions on your prescription label carefully, and ask your. Based on mechanism of action and published reports of effects in pregnant patients or animals, drug can cause fetal harm when administered to pregnant woman. Cyclophosphamide is an immunosuppressive agent that can be used for a variety of conditions in both dogs and cats. Mar 19, 2010 cyclophosphamide c 7 h 15 cl 2 n 2 o 2 p.
Up to eight cycles lasting 28 days each will be administered. Cyclophosphamide oral liquid is used in the treatment of many adult and pediatric malignancies. A plugin for the javabased pathvisio pathway editor has been developed to. Find the weglot translate settings page on the bottom left of your wordpress admin dashboard. Cytoxan cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide mono hydrate. The medicine works by crosslinking dna cells and suppressing the immune system. Cyclophosphamide fda prescribing information, side. One episode of renal tubular acidosis which progressed into chronic renal failure was reported. Incidence of cyclophosphamide induced urotoxicity and protective effect of mesna in rheumatic diseases. Cyclophosphamide has also been used as a single agent in the treatment of lowgrade lymphomas. Cyclophosphamide interferes with dna and other genetic factors within rapidly growing cells, leading to cell death.
The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have. As this emedtv page explains, cyclophosphamide is used for the treatment of nephritic syndrome in children and various types of cancer. Translate wp website weglot translate wordpress plugin. Add the diluent to the vial and gently swirl to dissolve the drug completely. If you notice that you have blood in the urine, you must tell your doctor straight away as they may need to stop giving you cyclophosphamide cadiasun. Cyclophosphamide is soluble in water, saline, or ethanol.
Cytoxan cyclophosphamide for injection, usp cytoxan tablets. Possible crosssensitivity with other alkylating agents can occur. Cyclophosphamide belongs to a class of drugs known as nitrogen mustardbased agents. Cyclophosphamide definition of cyclophosphamide by merriam. Cyclophosphamide definition of cyclophosphamide by. Cyclophosphamide cyc is an alkylating agent that was introduced into clinical practice as a chemotherapeutic agent but has also been used to treat a number of. Cyclophosphamide is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Consider the benefits of breastfeeding, the risk of infant drug exposure, and the risk of an untreated or inadequately treated condition. Cyclophosphamide is commonly used with doxorubicin hydroxydaunorubicin, vincristine oncovin, and prednisone known as the chop regimen, with or without other agents, in the treatment of various types of intermediategrade nonhodgkin lymphoma.
Cyclophosphamide interferes with oogenesis and spermatogenesis. The unchanged drug has an elimination halflife of 3 to 12 hours. Cyclophosphamide has a molecular formula of c 7 h 15 cl 2 n 2 o 2 ph 2 o and a molecular weight of 279. It is highly capable of reducing t and b lymphocytes. How to install a wordpress plugin 3 different methods. Computerized approach to creating a systematic ontology of. It is eliminated primarily in the form of metabolites, but from 5 to 25% of the dose is excreted in urine as unchanged drug. Cyclophosphamide is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. Cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous.
Jun, 20 cyclophosphamide has a molecular formula of c 7 h 15 cl 2 n 2 o 2 ph 2 o and a molecular weight of 279. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Place the mixture in an appropriate graduate, add sufficient oraplus or simple syrup to final volume, and mix well. Cyclophosphamide mg powder for solution for injection or infusion is packed in boxes containing 1, 5 or 10 clearcolourless type iglass 100 ml vials with bromobutyl rubber stopper, and flipoff seal with a sea green pp button. Pdf intravenous cyclophosphamide therapy in adults with. Stability of cyclophosphamide in extemporaneous oral suspensions. In an analogous way, the wp vocabulary can be used to capture the biological relations. Quality control samples were prepared by adding cyclophosphamide working stock solutions into simple syrup and oraplus to obtain final concentrations of 8, 12, and 18 mgml. Reconstitution in preparation for intravenous infusion. Once you have uploadedselected the file you want to create a download link for, as well as added the description text for your link, simply click on the blue insert into post or insert into page button. Phospharamide is the active metabolite that creates crosslinks in the dna. Towards the complete picture maastricht university. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for cytoxan cyclophosphamide. Paste your api key into the appropriate space under weglot translate settings, and click save.
Regular blood tests are important to detect bone marrow suppression. Cyclophosphamide is a prescription medicine that is licensed to treat certain kidney problems in children and various types of cancer. Cyclophosphamide is a class of medications called alkylating agents and is of the nitrogen mustard type. The chemical name for cyclophosphamide is 2 h1,3,2oxazaphosphorin2amine, n,nbis2chloroethyltetrahydro, 2oxide, monohydrate. Dec 15, 2008 cyclophosphamide, an alkylating agent, has been used as an immunosuppressant in the treatment of various autoimmune disorders and malignancies. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
This medicine is used to treat many types of cancer like lymphoma, myeloma, leukemia, breast cancer, and ovarian cancer, to name a few. Formation of cyclophosphamides active metabolite occurs mainly in the liver. Alkylating chemotherapy agents platinums, mustards, and other. It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Wordpress plugins allows you to easily modify, customize, and enhance a wordpress site. Each capsule for oral administration contains 25 mg or 50 mg cyclophosphamide anhydrous, usp and the following inactive ingredients. Cyclophosphamide is actually not particularly active as a chemical. Cyclophosphamide sye kloe foss fa mide is a chemotherapy drug. Cyclophosphamide should only be administered where there are facilities for regular monitoring of clinical, biochemical and haematological parameters before, during, and after administration and under the direction of a specialist oncology.
Listing a study does not mean it has been evaluated by the u. It can be used to treat lymphomas, leukemias, sarcomas, systemic lupus erythematosus, immune mediated hemolytic anemia, rheumatoid arthritis, etc. Cyclophosphamide tablets cyclophosphamide dose, indications. Stability of cyclophosphamide in extemporaneous oral. Oral versus intravenous administration of cyclophosphamide.
The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Medlineplus information on cyclophosphamide a lay language summary of important information about this drug that may include the. Cytoxan cyclophosphamide dosing, indications, interactions. Cytoxan cyclophosphamide for injection, usp cytoxan. Cyclophosphamide is indicated for the treatment of biopsy proven minimal change nephrotic syndrome in. It must be metabolized by the body to convert it in its active metabolite. Cyclophosphamide, although effective alone in susceptible malignancies, is more frequently used concurrently or sequentially with other antineoplastic drugs. Cyclophosphamide manufacturer pharmacological index.
Instead of changing the core program code of wordpress, you can add functionality with wordpress plugins. Guidelines for the administration of mesna with ifosfamide. Patients who cannot swallow cyclophosphamide pills will be converted to the same dose, given intravenously iv. Cyclophosphamide is also being studied in the treatment of other types of cancer. After the media uploader window closes, you will see the download link in the text editor window, utilizing the description text you set. To date, this knowledge has not been systematized, because of the lack of a.
Proteinuria and acidosis also occurred in rare instances. The risk of opportunistic infection such as pneumonia secondary to pneumocystic carinii increases drastically. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide. It occurs as a white, crystalline powder that liquefies upon the loss of its water of crystallization. Renal tubular acidosis, fanconi syndrome, renal rickets, and. Read through the plugin developer handbook to learn all about wordpress plugin development. Cyclophosphamide definition is an immunosuppressive and antineoplastic agent c7h15cl2n2o2p used especially in the treatment of lymphomas and some leukemias.